| Event | Date | Location | |
| Spring Training: Cleveland Indians vs San Diego Padres | Wed. Mar 10, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark |  |
| Spring Training: Oakland Athletics vs San Diego Padres | Sat. Mar 13, 2010 1:05PM | Phoenix, AZ - Phoenix Municipal Stadium | |
| Spring Training: Chicago White Sox vs San Diego Padres | Sat. Mar 20, 2010 1:05PM | Phoenix, AZ - Camelback Ranch Stadium | |
| Spring Training: Los Angeles Dodgers vs San Diego Padres | Sat. Mar 20, 2010 7:05PM | Phoenix, AZ - Camelback Ranch Stadium | |
| Spring Training: Chicago Cubs vs San Diego Padres | Sat. Mar 27, 2010 TBA | Mesa, AZ - Hohokam Park | |
| Spring Training: San Francisco Giants vs San Diego Padres | Sun. Mar 28, 2010 1:05PM | Scottsdale, AZ - Scottsdale Stadium | |
| Spring Training: Cincinnati Reds vs San Diego Padres | Tue. Mar 30, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Arizona Diamondbacks vs San Diego Padres | Mon. Apr 5, 2010 2:10PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs San Diego Padres | Tue. Apr 6, 2010 6:40PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs San Diego Padres | Wed. Apr 7, 2010 6:40PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Colorado Rockies vs San Diego Padres | Fri. Apr 9, 2010 TBA | Denver, CO - Coors Field | |
| Colorado Rockies vs San Diego Padres | Sat. Apr 10, 2010 TBA | Denver, CO - Coors Field | |
| Colorado Rockies vs San Diego Padres | Sun. Apr 11, 2010 TBA | Denver, CO - Coors Field | |
| San Diego Padres vs Atlanta Braves | Mon. Apr 12, 2010 3:35PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Atlanta Braves | Wed. Apr 14, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Atlanta Braves | Thu. Apr 15, 2010 3:35PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Arizona Diamondbacks | Fri. Apr 16, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Arizona Diamondbacks | Sat. Apr 17, 2010 5:35PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Arizona Diamondbacks | Sun. Apr 18, 2010 1:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs San Francisco Giants | Mon. Apr 19, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs San Francisco Giants | Tue. Apr 20, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs San Francisco Giants | Wed. Apr 21, 2010 TBA | San Diego, CA - Petco Park | |
| Cincinnati Reds vs San Diego Padres | Fri. Apr 23, 2010 TBA | Cincinnati, OH - Great American Ball Park | |
| Cincinnati Reds vs San Diego Padres | Sat. Apr 24, 2010 TBA | Cincinnati, OH - Great American Ball Park | |
| Cincinnati Reds vs San Diego Padres | Sun. Apr 25, 2010 TBA | Cincinnati, OH - Great American Ball Park | |
| Florida Marlins vs San Diego Padres | Mon. Apr 26, 2010 7:10PM | Miami Gardens, FL - LandShark Stadium (Formerly Dolphin Stadium) | |
| Florida Marlins vs San Diego Padres | Tue. Apr 27, 2010 7:10PM | Miami Gardens, FL - LandShark Stadium (Formerly Dolphin Stadium) | |
| Florida Marlins vs San Diego Padres | Wed. Apr 28, 2010 7:10PM | Miami Gardens, FL - LandShark Stadium (Formerly Dolphin Stadium) | |
| San Diego Padres vs Milwaukee Brewers | Thu. Apr 29, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Milwaukee Brewers | Fri. Apr 30, 2010 7:05PM | San Diego, CA - Petco Park | |
