| Event | Date | Location | |
| Spring Training: Pittsburgh Pirates vs Minnesota Twins | Sun. Mar 7, 2010 1:05PM | Bradenton, FL - Mckechnie Field |  |
| Spring Training: Philadelphia Phillies vs Minnesota Twins | Sat. Mar 13, 2010 1:05PM | Clearwater, FL - Bright House Networks Field | |
| Spring Training: Tampa Bay Rays vs Minnesota Twins | Wed. Mar 17, 2010 1:05PM | Port Charlotte, FL - Charlotte County Stadium | |
| Spring Training: Tampa Bay Rays vs Minnesota Twins | Sat. Mar 20, 2010 1:05PM | Port Charlotte, FL - Charlotte County Stadium | |
| Spring Training: Tampa Bay Rays vs Minnesota Twins | Thu. Mar 25, 2010 1:05PM | Port Charlotte, FL - Charlotte County Stadium | |
| MLB Exhibition: Minnesota Twins vs St. Louis Cardinals | Fri. Apr 2, 2010 TBA | Minneapolis, MN - Target Field | |
| MLB Exhibition: Minnesota Twins vs St. Louis Cardinals | Sat. Apr 3, 2010 TBA | Minneapolis, MN - Target Field | |
| Los Angeles Angels of Anaheim vs Minnesota Twins | Mon. Apr 5, 2010 TBA | Anaheim, CA - Angel Stadium | |
| Los Angeles Angels of Anaheim vs Minnesota Twins | Tue. Apr 6, 2010 TBA | Anaheim, CA - Angel Stadium | |
| Los Angeles Angels of Anaheim vs Minnesota Twins | Wed. Apr 7, 2010 TBA | Anaheim, CA - Angel Stadium | |
| Los Angeles Angels of Anaheim vs Minnesota Twins | Thu. Apr 8, 2010 TBA | Anaheim, CA - Angel Stadium | |
| Chicago White Sox vs Minnesota Twins | Fri. Apr 9, 2010 TBA | Chicago, IL - US Cellular Field | |
| Chicago White Sox vs Minnesota Twins | Sat. Apr 10, 2010 TBA | Chicago, IL - US Cellular Field | |
| Chicago White Sox vs Minnesota Twins | Sun. Apr 11, 2010 TBA | Chicago, IL - US Cellular Field | |
| Minnesota Twins vs Boston Red Sox | Mon. Apr 12, 2010 3:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Boston Red Sox | Wed. Apr 14, 2010 12:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Boston Red Sox | Thu. Apr 15, 2010 12:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Kansas City Royals | Fri. Apr 16, 2010 7:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Kansas City Royals | Sat. Apr 17, 2010 12:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Kansas City Royals | Sun. Apr 18, 2010 1:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Cleveland Indians | Tue. Apr 20, 2010 7:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Cleveland Indians | Wed. Apr 21, 2010 7:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Cleveland Indians | Thu. Apr 22, 2010 12:10PM | Minneapolis, MN - Target Field | |
| Kansas City Royals vs Minnesota Twins | Fri. Apr 23, 2010 TBA | Kansas City, MO - Kauffman Stadium | |
| Kansas City Royals vs Minnesota Twins | Sat. Apr 24, 2010 TBA | Kansas City, MO - Kauffman Stadium | |
| Kansas City Royals vs Minnesota Twins | Sun. Apr 25, 2010 TBA | Kansas City, MO - Kauffman Stadium | |
| Detroit Tigers vs Minnesota Twins | Tue. Apr 27, 2010 7:05PM | Detroit, MI - Comerica Park | |
| Detroit Tigers vs Minnesota Twins | Wed. Apr 28, 2010 7:05PM | Detroit, MI - Comerica Park | |
| Detroit Tigers vs Minnesota Twins | Thu. Apr 29, 2010 1:05PM | Detroit, MI - Comerica Park | |
| Cleveland Indians vs Minnesota Twins | Fri. Apr 30, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
