| Event | Date | Location | |
| Spring Training: Houston Astros vs Atlanta Braves | Sat. Mar 6, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium |  |
| Spring Training: Atlanta Braves vs Houston Astros | Sun. Mar 7, 2010 1:05PM | Lake Buena Vista, FL - Champion Stadium | |
| Spring Training: Houston Astros vs Toronto Blue Jays | Mon. Mar 8, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Spring Training: Houston Astros vs Florida Marlins | Wed. Mar 10, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Spring Training: Toronto Blue Jays vs Houston Astros | Fri. Mar 12, 2010 1:05PM | Dunedin, FL - Dunedin Stadium | |
| Spring Training: Houston Astros vs Washington Nationals | Sat. Mar 13, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Spring Training: Houston Astros vs Atlanta Braves | Sun. Mar 14, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Spring Training: Houston Astros vs Washington Nationals | Wed. Mar 17, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Spring Training: Houston Astros vs Toronto Blue Jays | Fri. Mar 19, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Spring Training: Houston Astros vs New York Yankees | Sat. Mar 20, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Spring Training: Houston Astros vs New York Mets | Sun. Mar 21, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Spring Training: Houston Astros vs St Louis Cardinals | Mon. Mar 22, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Spring Training: Pittsburgh Pirates vs Houston Astros | Tue. Mar 23, 2010 1:05PM | Bradenton, FL - Mckechnie Field | |
| Spring Training: Philadelphia Phillies vs Houston Astros | Thu. Mar 25, 2010 1:05PM | Clearwater, FL - Bright House Networks Field | |
| Spring Training: Houston Astros vs Pittsburgh Pirates | Fri. Mar 26, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Spring Training: Houston Astros vs Tampa Bay Rays | Sat. Mar 27, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Spring Training: Pittsburgh Pirates vs Houston Astros | Mon. Mar 29, 2010 1:05PM | Bradenton, FL - Mckechnie Field | |
| Spring Training: Houston Astros vs Philadelphia Phillies | Tue. Mar 30, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Spring Training: Atlanta Braves vs Houston Astros | Wed. Mar 31, 2010 1:05PM | Lake Buena Vista, FL - Champion Stadium | |
| Spring Training: Houston Astros vs Detroit Tigers | Thu. Apr 1, 2010 1:05PM | Kissimmee, FL - Osceola County Stadium | |
| Houston Astros vs San Francisco Giants | Mon. Apr 5, 2010 6:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs San Francisco Giants | Tue. Apr 6, 2010 7:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs San Francisco Giants | Wed. Apr 7, 2010 1:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs Philadelphia Phillies | Fri. Apr 9, 2010 7:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs Philadelphia Phillies | Sat. Apr 10, 2010 6:05PM | Houston, TX - Minute Maid Park | |
| Houston Astros vs Philadelphia Phillies | Sun. Apr 11, 2010 1:05PM | Houston, TX - Minute Maid Park | |
| St. Louis Cardinals vs Houston Astros | Mon. Apr 12, 2010 3:15PM | Saint Louis, MO - Busch Stadium | |
| St. Louis Cardinals vs Houston Astros | Wed. Apr 14, 2010 7:15PM | Saint Louis, MO - Busch Stadium | |
| St. Louis Cardinals vs Houston Astros | Thu. Apr 15, 2010 12:40PM | Saint Louis, MO - Busch Stadium | |
| Chicago Cubs vs Houston Astros | Fri. Apr 16, 2010 TBA | Chicago, IL - Wrigley Field | |
