| Event | Date | Location | |
| Chicago White Sox vs Cleveland Indians | Mon. Apr 5, 2010 TBA | Chicago, IL - US Cellular Field |  |
| Chicago White Sox vs Cleveland Indians | Wed. Apr 7, 2010 TBA | Chicago, IL - US Cellular Field | |
| Chicago White Sox vs Cleveland Indians | Thu. Apr 8, 2010 TBA | Chicago, IL - US Cellular Field | |
| Detroit Tigers vs Cleveland Indians | Fri. Apr 9, 2010 1:05PM | Detroit, MI - Comerica Park | |
| Detroit Tigers vs Cleveland Indians | Sat. Apr 10, 2010 1:05PM | Detroit, MI - Comerica Park | |
| Detroit Tigers vs Cleveland Indians | Sun. Apr 11, 2010 1:05PM | Detroit, MI - Comerica Park | |
| Cleveland Indians vs Texas Rangers | Mon. Apr 12, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Texas Rangers | Wed. Apr 14, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Texas Rangers | Thu. Apr 15, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Chicago White Sox | Fri. Apr 16, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Chicago White Sox | Sat. Apr 17, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Chicago White Sox | Sun. Apr 18, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Minnesota Twins vs Cleveland Indians | Tue. Apr 20, 2010 7:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Cleveland Indians | Wed. Apr 21, 2010 7:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Cleveland Indians | Thu. Apr 22, 2010 12:10PM | Minneapolis, MN - Target Field | |
| Los Angeles Angels of Anaheim vs Cleveland Indians | Mon. Apr 26, 2010 TBA | Anaheim, CA - Angel Stadium | |
| Los Angeles Angels of Anaheim vs Cleveland Indians | Tue. Apr 27, 2010 TBA | Anaheim, CA - Angel Stadium | |
| Los Angeles Angels of Anaheim vs Cleveland Indians | Wed. Apr 28, 2010 TBA | Anaheim, CA - Angel Stadium | |
| Cleveland Indians vs Minnesota Twins | Fri. Apr 30, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Minnesota Twins | Sat. May 1, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Minnesota Twins | Sun. May 2, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Toronto Blue Jays | Mon. May 3, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Toronto Blue Jays | Tue. May 4, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Toronto Blue Jays | Wed. May 5, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Detroit Tigers | Fri. May 7, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Detroit Tigers | Sat. May 8, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Detroit Tigers | Sun. May 9, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Kansas City Royals vs Cleveland Indians | Tue. May 11, 2010 TBA | Kansas City, MO - Kauffman Stadium | |
| Kansas City Royals vs Cleveland Indians | Wed. May 12, 2010 TBA | Kansas City, MO - Kauffman Stadium | |
| Kansas City Royals vs Cleveland Indians | Thu. May 13, 2010 TBA | Kansas City, MO - Kauffman Stadium | |
