| Event | Date | Location | |
| Spring Training: Cincinnati Reds vs Cleveland Indians | Fri. Mar 5, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark |  |
| Spring Training: Cleveland Indians vs Cincinnati Reds | Sat. Mar 6, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cleveland Indians vs Texas Rangers | Sun. Mar 7, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cleveland Indians vs San Diego Padres | Wed. Mar 10, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Chicago White Sox vs Cleveland Indians | Thu. Mar 11, 2010 1:05PM | Phoenix, AZ - Camelback Ranch Stadium | |
Spring Training: Cleveland Indians vs
Los Angeles Angels of Anaheim | Fri. Mar 12, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cleveland Indians vs Texas Rangers | Sat. Mar 13, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cleveland Indians vs San Francisco Giants | Tue. Mar 16, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cincinnati Reds vs Cleveland Indians | Wed. Mar 17, 2010 7:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cleveland Indians vs Cincinnati Reds | Thu. Mar 18, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: San Francisco Giants vs Cleveland Indians | Fri. Mar 19, 2010 1:05PM | Scottsdale, AZ - Scottsdale Stadium | |
| Spring Training: Cleveland Indians vs Oakland Athletics | Sat. Mar 20, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Los Angeles Dodgers vs Cleveland Indians | Sun. Mar 21, 2010 1:05PM | Phoenix, AZ - Camelback Ranch Stadium | |
| Spring Training: Chicago Cubs vs Cleveland Indians | Mon. Mar 22, 2010 TBA | Mesa, AZ - Hohokam Park | |
| Spring Training: Cleveland Indians vs Milwaukee Brewers | Tue. Mar 23, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cleveland Indians vs Seattle Mariners | Thu. Mar 25, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cleveland Indians vs Colorado Rockies | Fri. Mar 26, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cleveland Indians vs Arizona Diamondbacks | Sat. Mar 27, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cleveland Indians vs Los Angeles Dodgers | Mon. Mar 29, 2010 7:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cleveland Indians vs Chicago White Sox | Wed. Mar 31, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cleveland Indians vs Cincinnati Reds | Fri. Apr 2, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Spring Training: Cincinnati Reds vs Cleveland Indians | Sat. Apr 3, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Chicago White Sox vs Cleveland Indians | Mon. Apr 5, 2010 TBA | Chicago, IL - US Cellular Field | |
| Chicago White Sox vs Cleveland Indians | Wed. Apr 7, 2010 TBA | Chicago, IL - US Cellular Field | |
| Chicago White Sox vs Cleveland Indians | Thu. Apr 8, 2010 TBA | Chicago, IL - US Cellular Field | |
| Detroit Tigers vs Cleveland Indians | Fri. Apr 9, 2010 1:05PM | Detroit, MI - Comerica Park | |
| Detroit Tigers vs Cleveland Indians | Sat. Apr 10, 2010 1:05PM | Detroit, MI - Comerica Park | |
| Detroit Tigers vs Cleveland Indians | Sun. Apr 11, 2010 1:05PM | Detroit, MI - Comerica Park | |
| Cleveland Indians vs Texas Rangers | Mon. Apr 12, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
| Cleveland Indians vs Texas Rangers | Wed. Apr 14, 2010 TBA | Cleveland, OH - Progressive Field (formerly Jacobs Field) | |
