| Event | Date | Location | |
| Spring Training: Tampa Bay Rays vs Baltimore Orioles | Thu. Mar 4, 2010 1:05PM | Port Charlotte, FL - Charlotte County Stadium |  |
| Spring Training: Tampa Bay Rays vs Baltimore Orioles | Thu. Apr 1, 2010 1:05PM | Port Charlotte, FL - Charlotte County Stadium | |
| Tampa Bay Rays vs Baltimore Orioles | Tue. Apr 6, 2010 TBA | Saint Petersburg, FL - Tropicana Field | |
| Tampa Bay Rays vs Baltimore Orioles | Wed. Apr 7, 2010 TBA | Saint Petersburg, FL - Tropicana Field | |
| Tampa Bay Rays vs Baltimore Orioles | Thu. Apr 8, 2010 TBA | Saint Petersburg, FL - Tropicana Field | |
| Baltimore Orioles vs Toronto Blue Jays | Fri. Apr 9, 2010 TBA | Baltimore, MD - Oriole Park At Camden Yards | |
| Baltimore Orioles vs Toronto Blue Jays | Sat. Apr 10, 2010 TBA | Baltimore, MD - Oriole Park At Camden Yards | |
| Baltimore Orioles vs Toronto Blue Jays | Sun. Apr 11, 2010 TBA | Baltimore, MD - Oriole Park At Camden Yards | |
| Baltimore Orioles vs Tampa Bay Rays | Mon. Apr 12, 2010 TBA | Baltimore, MD - Oriole Park At Camden Yards | |
| Baltimore Orioles vs Tampa Bay Rays | Tue. Apr 13, 2010 TBA | Baltimore, MD - Oriole Park At Camden Yards | |
| Baltimore Orioles vs Tampa Bay Rays | Wed. Apr 14, 2010 TBA | Baltimore, MD - Oriole Park At Camden Yards | |
| Seattle Mariners vs Baltimore Orioles | Mon. Apr 19, 2010 7:10PM | Seattle, WA - Safeco Field | |
| Seattle Mariners vs Baltimore Orioles | Tue. Apr 20, 2010 7:10PM | Seattle, WA - Safeco Field | |
| Seattle Mariners vs Baltimore Orioles | Wed. Apr 21, 2010 7:10PM | Seattle, WA - Safeco Field | |
| Boston Red Sox vs Baltimore Orioles | Fri. Apr 23, 2010 TBA | Boston, MA - Fenway Park | |
| Boston Red Sox vs Baltimore Orioles | Sat. Apr 24, 2010 TBA | Boston, MA - Fenway Park | |
| Boston Red Sox vs Baltimore Orioles | Sun. Apr 25, 2010 TBA | Boston, MA - Fenway Park | |
| Baltimore Orioles vs New York Yankees | Tue. Apr 27, 2010 TBA | Baltimore, MD - Oriole Park At Camden Yards | |
| Baltimore Orioles vs New York Yankees | Wed. Apr 28, 2010 TBA | Baltimore, MD - Oriole Park At Camden Yards | |
| Baltimore Orioles vs New York Yankees | Thu. Apr 29, 2010 TBA | Baltimore, MD - Oriole Park At Camden Yards | |
| Baltimore Orioles vs Boston Red Sox | Fri. Apr 30, 2010 TBA | Baltimore, MD - Oriole Park At Camden Yards | |
| Baltimore Orioles vs Boston Red Sox | Sat. May 1, 2010 TBA | Baltimore, MD - Oriole Park At Camden Yards | |
| Baltimore Orioles vs Boston Red Sox | Sun. May 2, 2010 TBA | Baltimore, MD - Oriole Park At Camden Yards | |
| New York Yankees vs Baltimore Orioles | Mon. May 3, 2010 TBA | Bronx, NY - New Yankee Stadium | |
| New York Yankees vs Baltimore Orioles | Tue. May 4, 2010 TBA | Bronx, NY - New Yankee Stadium | |
| New York Yankees vs Baltimore Orioles | Wed. May 5, 2010 TBA | Bronx, NY - New Yankee Stadium | |
| Minnesota Twins vs Baltimore Orioles | Thu. May 6, 2010 7:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Baltimore Orioles | Fri. May 7, 2010 7:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Baltimore Orioles | Sat. May 8, 2010 12:10PM | Minneapolis, MN - Target Field | |
| Minnesota Twins vs Baltimore Orioles | Sun. May 9, 2010 1:10PM | Minneapolis, MN - Target Field | |
