| Event | Date | Location | |
| Spring Training: Chicago Cubs vs Arizona Diamondbacks | Fri. Mar 5, 2010 TBA | Mesa, AZ - Hohokam Park |  |
Spring Training: San Francisco Giants vs
Arizona Diamondbacks | Sat. Mar 6, 2010 1:05PM | Scottsdale, AZ - Scottsdale Stadium | |
| Spring Training: Cincinnati Reds vs Arizona Diamondbacks | Tue. Mar 9, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
Spring Training: Los Angeles Dodgers vs
Arizona Diamondbacks | Wed. Mar 10, 2010 1:05PM | Phoenix, AZ - Camelback Ranch Stadium | |
| Spring Training: Arizona Diamondbacks vs Oakland Athletics | Fri. Mar 12, 2010 1:05PM | Tucson, AZ - Tucson Electric Park | |
| Spring Training: Oakland Athletics vs Arizona Diamondbacks | Thu. Mar 18, 2010 1:05PM | Phoenix, AZ - Phoenix Municipal Stadium | |
| Spring Training: Chicago White Sox vs Arizona Diamondbacks | Wed. Mar 24, 2010 1:05PM | Phoenix, AZ - Camelback Ranch Stadium | |
| Spring Training: Cleveland Indians vs Arizona Diamondbacks | Sat. Mar 27, 2010 1:05PM | Goodyear, AZ - Goodyear Ballpark | |
| Arizona Diamondbacks vs San Diego Padres | Mon. Apr 5, 2010 2:10PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs San Diego Padres | Tue. Apr 6, 2010 6:40PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs San Diego Padres | Wed. Apr 7, 2010 6:40PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs Pittsburgh Pirates | Fri. Apr 9, 2010 6:40PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs Pittsburgh Pirates | Sat. Apr 10, 2010 5:10PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs Pittsburgh Pirates | Sun. Apr 11, 2010 1:10PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Los Angeles Dodgers vs Arizona Diamondbacks | Tue. Apr 13, 2010 TBA | Los Angeles, CA - Dodger Stadium | |
| Los Angeles Dodgers vs Arizona Diamondbacks | Wed. Apr 14, 2010 TBA | Los Angeles, CA - Dodger Stadium | |
| Los Angeles Dodgers vs Arizona Diamondbacks | Thu. Apr 15, 2010 TBA | Los Angeles, CA - Dodger Stadium | |
| San Diego Padres vs Arizona Diamondbacks | Fri. Apr 16, 2010 7:05PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Arizona Diamondbacks | Sat. Apr 17, 2010 5:35PM | San Diego, CA - Petco Park | |
| San Diego Padres vs Arizona Diamondbacks | Sun. Apr 18, 2010 1:05PM | San Diego, CA - Petco Park | |
| Arizona Diamondbacks vs St. Louis Cardinals | Mon. Apr 19, 2010 6:40PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs St. Louis Cardinals | Tue. Apr 20, 2010 6:40PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs St. Louis Cardinals | Wed. Apr 21, 2010 6:40PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs Philadelphia Phillies | Fri. Apr 23, 2010 6:40PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs Philadelphia Phillies | Sat. Apr 24, 2010 5:10PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Arizona Diamondbacks vs Philadelphia Phillies | Sun. Apr 25, 2010 1:10PM | Phoenix, AZ - Chase Field (formerly Bank One Ballpark) | |
| Colorado Rockies vs Arizona Diamondbacks | Mon. Apr 26, 2010 TBA | Denver, CO - Coors Field | |
| Colorado Rockies vs Arizona Diamondbacks | Tue. Apr 27, 2010 TBA | Denver, CO - Coors Field | |
| Colorado Rockies vs Arizona Diamondbacks | Wed. Apr 28, 2010 TBA | Denver, CO - Coors Field | |
| Chicago Cubs vs Arizona Diamondbacks | Thu. Apr 29, 2010 TBA | Chicago, IL - Wrigley Field | |
